Rates and cases of major sexually transmitted diseases in the U.S. have been increasing largely unabated, with more than 2.5 million cases of chlamydia, syphilis, and gonorrhea reported in 2021, the most recent year for which data from the Centers for Disease Control and Prevention is available.

According to CDC data, the state of Louisiana is in second place with 1,846 STD cases per 100,000 people. The total number of cases is 71,286. In comparison, Mississippi ranked first with 1,958 STD cases per 100,000 and 48,548 total cases.

Specifically, Louisiana is one of the states with the most gonorrhea and chlamydia cases. The CDC reports 32,997 chlamydia cases and 15,483 gonorrhea cases in the state.

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10. North Carolina

Total STD Rate: 922.2 per 100,000
Chlamydia Rate: 603.3 per 100,000
Gonorrhea Rate: 271.2 per 100,000
Syphilis Rate (cumulative): 47.7 per 100,000

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New Mexico Border

9. New Mexico

Total STD Rate: 925.9 per 100,000
Chlamydia Rate: 588 per 100,000
Gonorrhea Rate: 240.1 per 100,000
Syphilis Rate (cumulative): 97.8 per 100,000

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8. Arkansas

Total STD Rate: 942.4 per 100,000
Chlamydia Rate: 592.8 per 100,000
Gonorrhea Rate: 270.2 per 100,000
Syphilis Rate (cumulative): 79.4 per 100,000

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7. Georgia

Total STD Rate: 987.5 per 100,000
Chlamydia Rate: 629.1 per 100,000
Gonorrhea Rate: 296.3 per 100,000
Syphilis Rate (cumulative): 62.1 per 100,000

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6. Alabama

Total STD Rate: 989.6 per 100,000
Chlamydia Rate: 625.2 per 100,000
Gonorrhea Rate: 321.3 per 100,000
Syphilis Rate (cumulative): 43.1 per 100,000

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Getty Images/iStockphoto
Getty Images/iStockphoto

5. South Dakota

Total STD Rate: 1,009.1 per 100,000
Chlamydia Rate: 542 per 100,000
Gonorrhea Rate: 363.9 per 100,000
Syphilis Rate (cumulative): 103.2 per 100,000

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4. South Carolina

Total STD Rate: 1,052 per 100,000
Chlamydia Rate: 702.7 per 100,000
Gonorrhea Rate: 309.2 per 100,000
Syphilis Rate (cumulative): 40.1 per 100,000

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Getty Images/iStockphoto

3. Alaska

Total STD Rate: 1,091.2 per 100,000
Chlamydia Rate: 760.4 per 100,000
Gonorrhea Rate: 269.8 per 100,000
Syphilis Rate (cumulative): 61 per 100,000

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2. Louisiana

Total STD Rate: 1,159.9 per 100,000
Chlamydia Rate: 730.1 per 100,000
Gonorrhea Rate: 354.5 per 100,000
Syphilis Rate (cumulative): 75.3 per 100,000

Getty Images/iStockphoto
Getty Images/iStockphoto
Getty Images/iStockphoto

1. Mississippi

Total STD Rate: 1,266 per 100,000
Chlamydia Rate: 750 per 100,000
Gonorrhea Rate: 427.7 per 100,000
Syphilis Rate (cumulative): 88.3 per 100,000

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